NEW YORK » Kei Nishikori became the first man from Japan to reach the U.S. Open semifinals in 96 years, outlasting third-seeded Stan Wawrinka of Switzerland 3-6, 7-5, 7-6 (7), 6-7 (5), 6-4 on Wednesday.

The match went 4 hours, 15 minutes, and the 10th-seeded Nishikori managed to shake off any lingering exhaustion from his previous victory, which lasted 4:19 and ended at 2:26 a.m. Tuesday, equaling the latest finish in tournament history.

Nishikori began slowly against the Australian Open champion, but eventually got his bearings and used crisp returns and strong net play to edge ahead.

"Actually, I started a little bit tight, but my body was OK," Nishikori said in an on-court interview. "I don’t know how I finished … but I’m very happy."

In Saturday’s semifinals, Nishikori will face No. 1 Novak Djokovic or No. 8 Andy Murray, who each owns a U.S. Open title.

"Hopefully I can play 100 percent tennis next round," Nishikori said.

The last Japanese semifinalist at the U.S. Open was Ichiya Kumagae in 1918. No man from the country had made it to the final four at any major tournament since Jiri Satoh at Wimbledon in 1933.

Nishikori already was the first Japanese man to be ranked in the ATP’s top 10, having climbed to No. 9 in May. He came into the U.S. Open without a lot of proper preparation, because he was sidelined after having a cyst removed from his right foot in early August.

Nishikori, who is coached by 1989 French Open champion Michael Chang, had never eliminated top-10 opponents in consecutive matches at a major tournament. The fourth-round marathon win against No. 5 Milos Raonic put Nishikori in his second career Grand Slam quarterfinal; he lost in that round at the 2012 Australian Open.

Wawrinka had won 15 of his last 16 hard-court Grand Slam matches, a stretch that includes a run to his first major semifinal at last year’s U.S. Open and his first Grand Slam championship at the Australian Open.

He also had a lot less wear-and-tear on his body over the past 1 1/2 weeks, thanks in part to getting a walkover when the man he was supposed to play in the third round withdrew with an injury.

But in the end, it was Wawrinka who faltered down the stretch, getting broken to close the match when he slapped a forehand into the net. Nishikori did not really celebrate much, simply looking to the sky as he walked to the net. Chang leaped to his feet and pumped his fists in the stands.

While the 24-year-old Nishikori put on a brave face before facing Wawrinka, saying he expected to be fine, things did not appear to be OK in the early going. Between points, Nishikori would shake his arms or legs, or flex his hands. During a changeover, he placed a bag of ice on his forehead.

Both men were mostly content to remain anchored near the baseline, swapping booming groundstrokes in lengthy exchanges. And it was Wawrinka who got the better of most of that type of point in the first set, outmuscling Nishikori over and over.

Nishikori got his bearings in the second set, though, moving forward more often.

Nishikori came within two points of ending the match in the fourth-set tiebreaker, but his two errant groundstrokes sent the match to a fifth.

Djokovic and Murray were scheduled to play their quarterfinal Thursday night, after 17-time major champion Serena Williams took on 11th-seeded Flavia Pennetta of Italy in the women’s quarterfinals.

The Williams-Pennetta winner will face 17th-seeded Ekaterina Makarova of Russia next. The 26-year-old Makarova advanced to the first Grand Slam semifinal of her career with a 6-4, 6-2 victory over Victoria Azarenka, a two-time Australian Open champion and the runner-up to Williams at Flushing Meadows in 2012 and 2013.

Azarenka, a former No. 1 player who was seeded 16th after an injury-filled season, said she wasn’t able to practice Tuesday because of food poisoning. But she did not want to talk about how that might have affected her play against Makarova, who won the last four games.

"You can ask me 20 times the same question. I’m not going to make any excuses today," Azarenka said, shaking her head. "As I said, I did the best I could today. I want to give full credit to my opponent. She deserves to win. She played much better than me today. That’s it."