PARIS >> Venus Williams followed little sister Serena out of the French Open.

The elder Williams, a seven-time Grand Slam champion, lost to third-seeded Agnieszka Radwanska of Poland 6-2, 6-3 Wednesday in the second round.

Williams was playing at a major tournament for the first time since last August, when she withdrew before her second-round match at the U.S. Open. It was then that she revealed she had been diagnosed with Sjogren’s syndrome, a condition that can cause fatigue and joint pain.

On Tuesday, Serena Williams lost in the first round of a major tournament for the first time, falling to Virginie Razzano of France 4-6, 7-6 (5), 6-3.