BRUSSELS >> With Russian President Vladimir Putin the latest target of sanctions over the invasion of Ukraine, diplomatic appeals came second Saturday to imposing financial and military pain on Moscow as global condemnation grew.

The Biden administration said it was sending Ukraine up to $350 million in arms and other defensive supplies from U.S. Department of Defense stockpiles, with another $250 million possible. The Czech Republic and Slovakia said they were sending arms, and Slovakia’s defense minister said up to 1,200 foreign troops from other NATO members could be deployed in his country to reassure member countries on the alliance’s eastern flank.

In cities around the world, people spilled into the streets to protest the invasion and the potential for further upheaval. “This war will last, and all the crises that go with it will have durable consequences,” French President Emmanuel Macron warned.

White House press secretary Jen Psaki on Friday said the U.S. was preparing individual sanctions on Putin and Foreign Minister Sergey Lavrov, likely to include travel bans. The announcement came after the European Union announced it intended to freeze Putin’s assets, and British Prime Minister Boris Johnson told NATO leaders his country would sanction Putin and Lavrov. Canada said it would do the same.

Psaki said President Joe Biden hadn’t planned any more direct diplomatic overtures toward Putin, but “it does not mean we have ruled out diplomacy forever.” She said the U.S. would also newly sanction the Russian Direct Investment Fund, which functions as a sovereign wealth fund meant to draw capital into the Russian economy.

The U.S. measures block Putin and Lavrov from access to any assets within reach of U.S. officials, and bar anyone in the United States from doing business with them. Members of Russia’s security council also were sanctioned.

In response on Saturday, the deputy head of Russia’s Security Council, Dmitry Medvedev, said sanctions could offer Moscow a pretext for a review of its ties with the West, suggesting that Russia could cut them altogether. “We may look at each other in binoculars and gunsights,” he said. He also suggested that Russia could opt out of the New START nuclear arms control treaty that limits U.S. and Russian nuclear arsenals.

The U.S. and European allies earlier announced sweeping asset freezes and other penalties against Russia’s banks, state-owned enterprises and elites. On Saturday, triggered by the sanctions, French Marines patrolling the English Channel area intercepted a cargo ship sailing under the Russian flag for an investigation, the Maritime Prefecture said. Spokeswoman Veronique Magnin said it appeared to be the first such action in the Channel.

EU ministers have said further sanctions are possible, including kicking Russia out of SWIFT, the dominant system for global financial transactions. Separately, Canadian Prime Minister Justin Trudeau said Canada supports the removal of Russia from the SWIFT system.

Countries in Asia and the Pacific have joined the U.S., the EU and others in sanctioning Russian banks and leading companies and setting up export controls aimed at starving Russia’s industries and military of semiconductors and other high-tech products.

Australia on Saturday said it is imposing sanctions against all 339 members of the Russian parliament as well as eight Russian oligarchs close to Putin and is considering sanctions against Putin and Lavrov.

Japan and South Korea on Saturday said their foreign ministers had spoken with U.S. Secretary of State Antony Blinken. But Japanese Foreign Minister Yoshimasa Hayashi declined to say whether Japan plans to impose sanctions on Putin or Lavrov. South Korea’s foreign ministry said Blinken thanked South Korea over its willingness to participate in international sanctions against Russia, without details.

China, the only friend that might help Russia blunt the impact of sanctions, has continued to denounce sanctions and blamed the U.S. and its allies for provoking Moscow. Beijing, worried about American power in Asia, has increasingly aligned its foreign policy with Russia to challenge the West.

Russian chess legend and opposition politician Garry Kasparov described sanctions that don’t directly hit Putin as merely symbolic.

“As long as he controls hundreds of billions of dollars and looks invincible for his cronies in Russia, I don’t think that any protest on Russian streets will change anything,” Kasparov added in an interview with Sky News.