Honolulu police have opened a murder investigation after a man died of a stabbing early Sunday morning in Waianae.

According to police, the man was found with a fatal injury on Farrington Highway near Plantation Road shortly before 2 a.m.

A witness reported three men involved in an altercation and two of those men fled on foot, according to a Honolulu police report. The witness reported that the victim, described as in his late 20s to early 30s, was stabbed and in the middle of the road. The victim’s identity was not immediately released.

A Honolulu Emergency Medical Services report said paramedics treated the critically injured man for to his upper torso stab wounds at Pililaau Community Park at 2:09 a.m. He was pronounced dead at 2:50 a.m., authorities said.

Police said the stabbing did not appear to be a random act. Anyone with information is asked to call 911 or CrimeStoppers Honolulu at 808-955-8300. No arrests had been made as of Sunday.