CHICAGO >> Chicago parents and community groups are scrambling to prepare for a massive teachers’ strike set to begin Thursday, prompting the city to preemptively cancel classes in the nation’s third-largest school district.

The Chicago Teachers Union confirmed tonight that its 25,000 members would not return to their classrooms Thursday after months of negotiation between the union and Chicago Public Schools failed to resolve disputes over pay and benefits, class size and teacher preparation time.

The strike is Chicago’s first major walkout by teachers since 2012 and city officials announced early today that all classes had been canceled for Thursday in hopes of giving more planning time to 300,000 students’ families.

During the 2012 strike, the district kept some schools open for half days during a seven-day walkout. District officials said this time they will keep all buildings open during school hours, staffed by principals and employees who usually work in administrative roles.

Breakfast and lunch will be served, but all after-school activities and school buses are suspended in the district serving more than 300,000 students.

June Davis said if teachers strike, she would likely send her 7-year-old son, Joshua, to his usual elementary school — Smyth Elementary on the city’s South Side where almost all students are low-income and minority.

Davis, 38, said she would otherwise have to take her son to his grandmother’s in a southern suburb, requiring an hourlong trip on a regional bus line.

“Everybody’s hoping they will come to some kind of agreement, find some compromise,” Davis said.

Janice Jackson, the district’s CEO, said earlier this week that more than 80% of families with students in Chicago’s public schools are considered low-income.

“We have parents, who if they don’t go to work, they don’t get paid,” Jackson said. “So, we need to make sure that there is a place for their children to go so that they can continue doing what they need to do to support their families.”

Talks continued Wednesday but Mayor Lori Lightfoot preemptively announced that classes on the following day would be canceled, saying she wanted to give parents more time to plan. The union tonight announced that the teachers would go on strike Thursday.

A clearly frustrated Lightfoot said earlier that the city has not only offered a 16% pay raise over the 5-year contract, but the city has also agreed to put language in the contract that addresses “enforceable targets” on class size and increasing staffing levels for positions such as nurses, librarians and social workers — items the union said were critical.

She said the union’s demands would cost an unaffordable $2.5 billion a year.

“Without question, the deal we put on the table is the best in the Chicago Teachers union history,” said Lightfoot. “Despite all this, the Chicago Teachers Union intends to forge ahead with a strike.”

Union leaders, though, disputed Lightfoot’s characterization of the city’s willingness to concede to their demands on several issues, including class sizes.

“CPS’ current class size offer falls far short of what’s needed to address the sweeping scale of the problem,” they said in a statement.

Lightfoot said the city agreed to make substantial changes on some of the union’s top priorities, but its negotiators responded by issuing additional demands, including some she deemed unacceptable.

“The union is still demanding to shorten instructional time by 30 minutes in the morning,” she said. “We won’t do that. We will not cheat our children out of instructional time.”

Before heading into a downtown law firm for bargaining talks Wednesday morning, union vice president Stacy Davis Gates said there is a “gross disconnect” between Lightfoot’s comments and what negotiators have put in writing.

“To say that you have offered a proposal that respects what we are asking for, to say you’ve bent over backward … it’s absolutely ridiculous,” Davis Gates said.

Community organizations have been preparing for days to welcome students, ranging from a $100 per day camp for elementary school kids at the Shedd Aquarium to all-day programs run by the Boys & Girls Club of Chicago and accessible for a $20 annual membership fee.

Mimi LeClair, president of the Boys & Girls Club of Chicago, said a strike is particularly difficult for single parents and those whose jobs have inflexible schedules.

“It’s a horrendous dilemma, deciding between likely losing their job or having their paycheck docked when they rely on every penny or leaving their children home alone,” LeClair said.

The city’s public libraries also are planning programs for students, along with a network of churches and community centers that are part of the city’s Safe Haven program intended to give kids a safe place during the summer months particularly on the city’s south and west sides.

The YMCA of Metro Chicago expects highest demand for its all-day programs for children between the ages of 5 and 12, who are too young to stay home alone but whose parents may oppose sending them to schools unstaffed by teachers.

“Real life still happens,” said Man-Yee Lee, a spokeswoman for the organization. “Parents still need to go to work and their kids still need somewhere to go.”