Honolulu will witness a “first” and a “last” Saturday when Marie Osmond takes the stage at the Blaisdell Arena. It will be Osmond’s first appearance in the arena as a concert headliner, and she’ll be doing it on her 59th birthday. It will also be the last time that her four brothers — Alan, Wayne, Merrill and Jay — will perform together in a public concert. Alan’s son David will also join in.

“I’ve always worked on my birthday,” Osmond explained in a call from her home in Las Vegas. But this year she had her birthday week off. “All of a sudden I had this really crazy feeling from my parents to ‘do one last show with your brothers.’

“It was crazy. I thought, ‘Alan’s retired. Wayne will never do another show. I work with Donny, I don’t work with my other brothers, but we’re not getting any younger. Is this even a possibility?’”

She called Alan first and asked for the special birthday present. Then she asked each of the others.

The show will celebrate the brothers’ six decades in music, then her career — from the remake of “Paper Roses,” her 1973 hit, to her work on Broadway, to songs from her current album, “Music Is Medicine.” Merrill and Jay will be her partners on the duets she originally recorded with other vocalists.

Osmond says the night is as much about her brothers as it is about her.

“I’m so excited about this! I think it’s going to be a really amazing moment. I have fans who are flying over from England, they’re flying from Sweden, they’re flying from Denmark and Australia, and they’re going to be there in Hawaii for the last performance of the four brothers — there will be no more. … You will never see those original four Osmonds on stage again.”

Donny and Marie’s older siblings started out as the Osmond Brothers in 1962, joined a year later by Donny.

“I have never heard any boy band or anything else (that) had the harmonies of my brothers,” Osmond said. “It’s crazy awesome. They started it all. These guys have sold 100 million records. There’s not many people who can say that in our business, and I don’t believe they’ve had the honor and the accolades that I think they deserve. I am who I am because of those guys and their work ethic and everything else.”

The only girl — and next to youngest — of nine siblings, Osmond grew up with her brothers as role models. Alan, Jay, Merrill, Wayne and Donny were already veteran entertainers when the Jackson 5’s debut single, “I Want You Back,” topped the Billboard Hot 100 singles chart early in 1970. Within a year, the Osmond Brothers had become the Osmonds, switching from barbershop harmonies to a Top 40/R&B-lite sound. Their debut single, “One Bad Apple,” topped the Billboard Hot 100 singles chart for five weeks, followed by a string of hits that included “Double Lovin’,” “Yo-Yo,” “Crazy Horses” and their hard-driving concert closer, “Down by the Lazy River.”

Donny moved into a solo career, Marie topped Billboard’s country chart with a poignant remake of the 1960 Anita Bryant hit “Paper Roses,” and the youngest Osmond of all, “Little Jimmy,” achieved international success with his remake of a novelty song, “Long Haired Lover from Liverpool.”

Donny and Marie have been the most visible Osmonds in the years since. They were the genial co-hosts of “The Donny & Marie Show,” a variety show that ran on ABC from 1976 to 1979, and came to Hawaii to film “Goin’ Coconuts,” described as a “musical adventure comedy,” in 1978.

Donny and Marie remain a strong team. They opened in Las Vegas in 2008 in what was supposed to be a six-week engagement and are still there — they reopen Tuesday in the Donny and Marie Showroom at the Flamingo Las Vegas.

Osmond is also celebrating the success of her “Music Is Medicine,” an impressive collection of powerful contemporary songs that include guest performances by Olivia Newton-John, John Rich and SisQo.

The album has been defined it as “country” — possibly because Osmond had a string of country hits in the 1970s — but the arrangements are closer to mainstream rock and pop.

Osmond can do without conventional labels. “In (the song) ‘Music Is Medicine’ there’s a line: ‘That they categorize it only makes me mad. There’s only two kinds, good and bad.’ And that’s how I believe it is with music, a good song is a good song,” she said.

She added that music and “good songs” have always been important to her: “Music has been there through some of the good times and the bad times and the in-between times. I love music.”

Was it difficult being the only girl in a family of boys? She laughs.

“I don’t know what to liken it to. Would I have loved to have had a sister? Yes, it would have been great. Were there times I missed having a sister? I’m sure I did, but I had a great mother, and a unique life. I started (entertaining) at 3 when Donny and I were the little novelty children who came out to sing with the Osmond Brothers. Then, growing up, I worked with Frank Sinatra, Sammy Davis Jr. — who taught me how to walk on stage — and Dean Martin and Ethel Merman and Groucho Marx — the dirty old man pinched my butt! …

“Work to me was always about becoming better at your craft and loving people. I was talking to my sweet friend, Olivia Newton-John, and we were saying there’s not many of us five-decades females in this business that have worked consistently and are still selling albums and doing concerts and being successful. I would definitely not be here if not for the fans. I feel very blessed.”