Walgreen Co., the nation’s largest drugstore chain, is reopening its flagship Honolulu store across from Ala Moana Center on Saturday.

The new two-story store at 1488 Kapiolani Blvd. opening at 9 a.m. will offer an "extensive selection of products and services unexpected from a drugstore," the Deerfield, Ill.-based retailer said in a press release.

The retailer spent $39 million acquiring the sites several years ago as part of establishing its first store in the state, which opened in 2007 in the remodeled space of a former Tower Records. Walgreen then demolished the building to make way for a bigger store with a three-level parking garage.

The first floor of the store features an Upmarket Cafe, including a made-to-order juice bar, sushi, poke and sashimi, as well as wraps, sandwiches and salads, baked goods and frozen yogurt.

Beer, wine and spirits will also be available on the first floor along with souvenirs and apparel. On the second floor is a pharmacy, which will have an express pickup kiosk to allow customers to quickly pick up and pay for refill prescriptions. It also will include a private health room for counseling and services such as immunizations and health tests.

The location will include a LOOK Boutique beauty department, which offers an expanded selection of skin and hair care and cosmetics.

The store will be open 24 hours a day, seven days a week; pharmacy hours are 7 a.m. to 10 p.m. weekdays, 8 a.m. to 7 p.m. on weekends.

Walgreen officials will mark the 35,576-square-foot store’s opening with a private Hawaiian blessing at 8 a.m. The company also is making a $5,000 donation to the Hawaii chapter of the American Diabetes Association.